Saturday, March 05, 2022

Solid State Sensors To Detect COVID Virus?

First of all, I'm not sure why this is called "Quantum sensor". Maybe it is because it is using solid-state physics principles?

This is an interesting report, and if the simulation is valid, I'm hoping that such devices will be made real soon because it has the ability to detect other types of viruses. It really is a solid state sensor that makes use of solid state physics principles.

In the presence of viral RNA, these pairs will detach from the nanodiamond surface thanks to a process called c-DNA and virus RNA hybridization. The newly formed c-DNA-Gd3+/RNA compound will then freely diffuse in solution, thereby increasing the distance between the magnetic Gd and the nanodiamond. As a result of this increased distance, the NV centres will sense less magnetic “noise” and thus have a longer T1 time, which manifests itself in a larger fluorescence intensity.

By optically monitoring the change in relaxation time using a laser-based sensor, the researchers say they could identify the presence of viral RNA in a sample and even quantify the number of RNA molecules. Indeed, according to their simulations, Cappellaro, Kohandel and colleagues, who report their work in Nano Letters, say that their technique could detect as few as a few hundred strands of viral RNA and boast an FNR of less than 1%, which is much lower than RT-PCR even without the RNA amplification step. The device could also be scaled up so that it could measure many samples at once and could detect RNA viruses other than SARS-CoV-2, they add.

I find this interesting because as students in solid-state physics, one of the first thing that the students encounter in such a course is the study of solid-state crystal lattice. This includes the type of defects in a crystal lattice, such as vacancies and impurities. So this diamond NV center is exactly those two types of defect in the lattice. Imagine that something you learned during the first couple of weeks of a course in school actually has a humongous application to human well-being!

Chalk this one up as another invaluable application from condensed matter physics.

Zz.

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