Physics thriller... hum.... when was the last time you see those 2 words together? :)
In any case, this article from Symmetry magazine is quite entertaining. It is a review and an interview with author Mark Alpert regarding his new novel "Final Theory". Most of the setting for this novel is set at Fermilab.
So hey, if Dan Brown can use CERN for "Angels and Demons", someone else certainly can use Fermilab for another thriller, no? :)